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FLASH GENE
Symbol KCTD1 contributors: mct/npt/pgu - updated : 25-05-2013
HGNC name potassium channel tetramerisation domain containing 1
HGNC id 18249
DNA
TYPE functioning gene
STRUCTURE 202.50 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located colocalizes with TFAP2A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2174 29.3 257 - 2008 18358072
5 - 3438 96.3 865 - 2008 18358072
6 - 1754 29.3 257 - 2008 18358072
5 - 1715 - 257 - 2008 18358072
  • also called KCTD 1N
  • complete BTB domain
  • 5 - 1671 - 271 - 2008 18358072
    also called KCTD 1C
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly conserved BTB domain in its N terminus (N-terminal broad-complex, tramtrack, and bric-a-brac (BTB) domain) , which can facilitate protein-protein interactions that may be involved in the regulation of signaling pathways
  • a potassium-channel tetramerization domain (KCTD)
  • HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text completely co-localized with TFAP2A in the nuclei of cells
    basic FUNCTION
  • transcriptional repressor mediates homomeric protein-protein interactions
  • plays important roles in controlling the expression of specific genes in breast cancer
  • functioning as a transcriptional repressor and mediating homomeric protein-protein interactions
  • having a function as the transcriptional repressor for AP-2 family, especially for TFAP2A)
  • acting as a potent transcriptional repressor and inhibiting the transcriptional activity via its BTB domain, though KCTD1 transcriptional repression is unaffected by the HDAC inhibitors, trichostatin A, and sodium butyrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with TFAP2A (significantly repressed TFAP2A-mediated transactivation through the BTB domain, and specifically acts as a negative regulator of TFAP2A)
  • interacted with three major members of the AP-2 family and inhibited their transcriptional activities
  • molecular interaction partners of the cellular prion protein (PRNP)
  • interacting with the AP-2alpha family of transcription factors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SENS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS