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FLASH GENE
Symbol KCNIP1 contributors: npt/mct - updated : 18-12-2010
HGNC name Kv channel interacting protein 1
HGNC id 15521
DNA
TYPE functioning gene
STRUCTURE 382.75 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2053 - 227 brain, cerebellum, spinal cord, testis 2005 16112838
exon 1a
8 - 2020 - 216 brain, cerebellum, spinal cord 2005 16112838
exon 1b
8 - 1518 - 225 - 2005 16112838
- - 726 - 241 - 2005 16112838
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum predominantly Homo sapiens
 braindiencephalonhypothalamus predominantly Homo sapiens
 braindiencephalonthalamus highly Homo sapiens
 brainbasal nucleistriatum highly Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four EF-hand-like motifs (calcium binding motif), intact EF-hands 3 and 4 were crucial for the anchorage of KCNIP1 on membrane
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Kcnip1
    homolog to rattus Kcnip1
    homolog to Drosophila CG5890
    homolog to C.elegans F21A10.1
    Homologene
    FAMILY
  • recoverin/NCS subfamily of calcium-binding proteins
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulating subunit modulating Kv4 (potassium voltage dependant) channel activity and neuronal excitability
  • stimulate the traffic of KCND2 channels to the plasma membrane (Venn 2008)
  • might play pivotal roles in the GABAergic inhibitory system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
  • KCND1, KCND2, KCND3 (alpha subunits)and KCNIP1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein binding with phospholipid vesicles induced a change in the structure of KCNIP1 in the presence of phosphatidylserine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS