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FLASH GENE
Symbol KCNE4 contributors: mct - updated : 08-06-2011
HGNC name potassium voltage-gated channel, Isk-related family, member 4
HGNC id 6244
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 3.49 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box) (TATA box)
Binding site   transcription factor
text structure binding sites for MYOD1, E4F1, USF1
MAPPING cloned Y linked N status provisional
Physical map
CHPF 2q36.1 chondroitin polymerizing factor LOC130612 2q36.1 similar to RIKEN cDNA A230078I05 gene KIAA0657 2q36.1 similar to RIKEN cDNA A230078I05 gene INHA 2q33-q34 inhibin, alpha STK11IP 2q36 serine/threonine kinase 11 interacting protein SLC4A3 2q36 solute carrier family 4, anion exchanger, member 3 EPHA4 2q36.1 EphA4 LOC130600 2q36.1 similar to ribosomal protein L23 LOC266724 2q36.3 heat shock 70kDa protein 9B pseudogene PAX3 2q36.1-q36.2 paired box gene 3 (Waardenburg syndrome 1) FLJ32447 2q36.1 hypothetical protein FLJ32447 SGPP2 2q36.3 sphingosine-1-phosphate phosphotase 2 FARSLB 2q36.1-q36.2 phenylalanine-tRNA synthetase-like, beta subunit DGAT2L1 2q36.3 diacylglycerol O-acyltransferase 2 like 1 LOC391486 2 similar to ribosomal protein L31 FACL3 2q34 fatty-acid-Coenzyme A ligase, long-chain 3 KCNE4 2q36.3 potassium voltage-gated channel, Isk-related family, member 4 SCG2 2q35-q36 secretogranin II (chromogranin C) LOC391487 2 similar to transcription factor-like protein 4 isoform beta; MAX-like bHLHZIP protein; MAX-like protein X; BigMax protein AP1S3 2q36.3 adaptor-related protein complex 1, sigma 3 subunit WDFY1 2q36.2 WD repeat and FYVE domain containing 1 MRPL44 2q36.3 mitochondrial ribosomal protein L44 SERPINE2 2q33-q35 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 LOC391488 2 similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease) FLJ22746 2q36.3 hypothetical protein FLJ22746 CUL3 2q36.3 cullin 3 DOCK10 2q24.1-q36.3 dedicator of cytokinesis 10 KIAA1486 2q36.3 KIAA1486 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2976 - 170 - 2003 12670483
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   predominantly Homo sapiens
Nervousbrain   predominantly Homo sapiens
Reproductivefemale systemovary   
 male systemtestis  predominantly Homo sapiens
 male systemprostate   
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text moderately in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycosylation site
  • a transmembrane domain
  • a cytoplasmic domain of KCNE4 that is necessary for its inhibition of KCNQ1
  • a tetraleucine motif in the juxtamembrane region of the C terminus , interacting with KCNQ1
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Kcne4
    intraspecies homolog to KCNE1
    Homologene
    FAMILY potassium channel E family
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • ancillary protein modulating the gating kinetics and enhance stability of the multimeric complex
  • inhibiting potassium current by inhibiting KCNQ1 activation
  • may act as a subunit of KCNJ2 channel to modulate the potassium channel function
  • functions as an inhibitory KCNA3 partner in leukocytes
  • KCNE4 association might play a crucial role in controlling immunological responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • potassium channel alpha subunit, like KCNQ1
  • directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may coassemble with KCNQ subunits
  • has a dramatic inhibitory effect on KCNQ1 that differs substantially from the activating effects of KCNE1 and KCNE3
  • associates with KCNA3 in the ER and decreases the number of KCNA3 channels at the cell surface, which diminishes cell excitability
  • modulate KCND current activation, inactivation and recovery from inactivation, in a KCNIP2-dependent manner
  • can biochemically interact with CALM1 and this interaction is Ca(2+)-dependent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus
  • interaction between KCNE4 and CALM1 could be involved in the modulation of KCNQ1 by KCNE4
  • CALM1-KCNE4 interactions might constitute part of a feedback loop for regulating intracellular Ca2+
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS