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FLASH GENE
Symbol IL22RA1 contributors: mct - updated : 09-04-2019
HGNC name interleukin 22 receptor, alpha 1
HGNC id 13700
DNA
TYPE functioning gene
STRUCTURE 23.35 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C1QA 1p36.3-p34.1 complement component 1, q subcomponent, alpha polypeptide C1QG 1p36.3-p34.1 complement component 1, q subcomponent, gamma polypeptide C1QB 1p36.11 complement component 1, q subcomponent, beta polypeptide EPHB2 1p36.1-p35 EphB2 LOC127309 1p36.11 similar to RIKEN cDNA 4930549C01 KIAA0601 1p36.11 KIAA0601 protein LUZP1 1p36 leucine zipper protein 1 LOC391018 1 similar to RIKEN cDNA 2410002F23 HTR1D 1p35 5-hydroxytryptamine (serotonin) receptor 1D LOC391019 1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) HNRPR 1p36.11 heterogeneous nuclear ribonucleoprotein R ZNF436 1p36 zinc finger protein 436 TCEA3 1p36.11 transcription elongation factor A (SII), 3 UPLC1 1p36.11 up-regulated in liver cancer 1 E2F2 1p36.11 E2F transcription factor 2 ID3 1p36.13-36.12 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein AD7C-NTP 1p36 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein RPL11 1p36.1-p35 ribosomal protein L11 TCEB3 1p36.1 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) HT014 1p36.11 HT014 LYPLA2 1p36.12-p35.1 lysophospholipase II GALE 1p36-p35 galactose-4-epimerase, UDP- HMGCL 1p36.11 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) FUCA1 1p36.1 fucosidase, alpha-L- 1, tissue FLJ35961 1p36.11 hypothetical protein FLJ35961 IL22RA1 1p36.11 interleukin 22 receptor, alpha 1 IL28RA 1p36.11 interleukin 28 receptor, alpha (interferon, lambda receptor) SOM 1p36.11 sister-of-mammalian grainyhead LOC90529 1p36.11 hypothetical protein LOC90529 DJ462O23.2 1p36.12-p35.1 hypothetical protein dJ462O23.2 DSCR1L2 1p35.3-p33 Down syndrome critical region gene 1-like 2 SRRM1 1p36.11 serine/arginine repetitive matrix 1 CLIC4 1p36.11 chloride intracellular channel 4 RUNX3 1p36.11 runt-related transcription factor 3 LOC391020 1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) P29 1p36.13-p35.1 GCIP-interacting protein p29 DJ465N24.2.1 1p36.13-p35.1 hypothetical protein dJ465N24.2.1 SMP1 1p36.11 hypothetical protein dJ465N24.2.1 RHCE 1p36.1 Rhesus blood group, CcEe antigens
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2811 63 574 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivemale systemprostate   
cell lineage
cell lines colorectal adenocarcinoma, lung carcinoma, melanoma, hepatoma, renal carcinoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an extracellular domain
  • two fibronectin type III (FnIII) domains
  • glycosylation sites
  • a transmembrane domain
  • an intracellular domain with four potential Stat3 recruitement motifs (YXXQ)
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il22r
    intraspecies homolog to IL22RA2
    Homologene
    FAMILY
  • type II cytokine receptor family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in the recruitment of Stat proteins
  • the role of the IL22/IL22RA1 axis in cancer is complex and context-specific
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the membranar receptor of IL22
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to IL22, Stat3, Jak1, CRF2-4, IL22RA, IL22RA1 and IL-20RB
  • IL22 secreted by decidual stromal cells (DSCs) and decidual natural killer (dNK) cells might promote the survival of trophoblasts and participate in the maintenance of pregnancy by binding to the IL22RA1
  • increased expression of IL22RA1 promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL22
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to preeclampsia (PE)
  • Variant & Polymorphism other IL22RA1 rs3795299 may be associated with the development of preeclampsia (PE)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS