basic FUNCTION
| transducing extracellular signals through heterotrimeric G protein |
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may play a role in energy metabolism (Cai 2008) |
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playing a critical role in lactate-mediated suppression of adipose lipolysis (Cai 2008) |
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lactate and its receptor HCAR1 unexpectedly function in an autocrine and paracrine loop to mediate insulin-induced antilipolytic effects |
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for the AAs important for HCAR1 function, the corresponding AAs or motifs in HCAR2 are also critical for HCAR2 function |
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HCAR1, HCAR2 are G protein-coupled receptors located predominantly on adipocytes that mediate anti-lipolytic effects |
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HCAR1, HCAR2 are positively correlated with PPARG gene expression in fat |
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is important for cancer cell regulation of lactate transport mechanisms, furthermore, lactate transport is important for the survival of cancer cells in the tumor |
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lactate receptor, which promotes lipid storage in adipocytes, and is also active in the mammalian brain |