Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPR101 contributors: mct - updated : 25-05-2022
HGNC name G protein-coupled receptor 101
HGNC id 14963
DNA
TYPE functioning gene
STRUCTURE 10.07 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • GPR101 distal promoter is capable of driving gene expression in human embryonic cellular contexts
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 8032 - 508 - 2006 16647048
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary    Homo sapiensFetal
    Nervousbraindiencephalonhypothalamussuprachiasmatic nucleihighly Homo sapiens
    Reproductivemale systemprostate  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Gpr101 (72.8 pc)
    homolog to murine Gpr101 (72.2 pc)
    Homologene
    FAMILY
  • G protein coupled receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transducing extracellular signals through heterotrimeric G proteins
  • acting as an orphan receptor
  • participates in a potentially wide range of activities in the CNS via modulation of cAMP levels
  • important role likely for GPR101 in brain and pituitary development
  • seems to play a role in the normal development of the GHRH-GH axis
  • might be important in regulating diverse functions such as energy balance and reproduction
  • role of GPR101 and SOX3 in pituitary function
  • crucial contribution of GPR101 misexpression in the hormonal regulation of body growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) XAGG
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS