basic FUNCTION
| may be modulating MSH6 expression |
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may be recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation |
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ubiquitination and degradation |
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acting as a Nedd8 ligase for TP53 |
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protein arginine methyltransferase, that symmetrically dimethylates arginine residues |
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plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes |
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haplo-insufficient tumour suppressor gene |
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promotes the degradation of DTL during an unperturbed cell cycle to promote efficient progression through S and G 2/M phases of the cell cycle |
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BTRC, FBXW7, FBXL14, FBXO45, FBXL5, FBXO11 play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins |