Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FBXO11 contributors: mct/npt/pgu - updated : 19-10-2016
HGNC name F-box protein 11
HGNC id 13590
DNA
TYPE functioning gene
STRUCTURE 99.47 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 4070 - 927 - 2007 1709874
18 - 2567 76.4 686 - 2007 1709874
16 - 2154 65.43 585 - 2007 1709874
23 - 3859 94 843 - 2007 1709874
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrainforebraincerebral lobefrontal 
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connective    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
Skin/Tegumentkeratinocyte
Skin/Tegumentmelanocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal 40 amino acid F-box motif common to all F-box protein family members
  • 19 PbH1 repeats
  • a large domain with homology to the bacterial periplasmic protein NosD, a component of the nitrous oxide reductase complex
  • a zinc finger-like domain called a UBR box at the C terminus, 70-AAs UBR box functioning as a common structural element essential for binding to all known destabilizing N-terminal residues
  • HOMOLOGY
    interspecies ortholog to murine Fbxo11
    ortholog to rattus fbxo11
    Homologene
    FAMILY
  • F-box protein family
  • PRMT family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • BCL6 and FBXO11 co-localized in the nucleus where they showed overlapping, punctate staining throughout the nucleoplasm
  • basic FUNCTION
  • may be modulating MSH6 expression
  • may be recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation
  • ubiquitination and degradation
  • acting as a Nedd8 ligase for TP53
  • protein arginine methyltransferase, that symmetrically dimethylates arginine residues
  • plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes
  • haplo-insufficient tumour suppressor gene
  • promotes the degradation of DTL during an unperturbed cell cycle to promote efficient progression through S and G 2/M phases of the cell cycle
  • BTRC, FBXW7, FBXL14, FBXO45, FBXL5, FBXO11 play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Skp1-Cullin1-F-box (SCF) complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with TP53 (inhibits p53 activity without affecting its stability, and promoting the neddylation of TP53)
  • directly controls the ubiquitin-mediated degradation of BCL6 and FBXO11-dependent degradation of BCL6 is ERK-independent
  • interacts with DTL, a DCAF protein that controls cell-cycle progression, and recruits DTL to the SCF(FBXO11) complex to promote its proteasomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in vitiligo melanocytes
    tumoral   deletion   loss of function
    in multiple diffuse large B-cell lymphoma (DLBCL)cell lines, and this inactivation of FBXO11 correlated with increased levels and stability of BCL6
    Susceptibility to vitiligo
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS