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FLASH GENE
Symbol ZFP36L1 contributors: mct/ - updated : 05-03-2011
HGNC name zinc finger protein 36, C3H type-like 1
HGNC id 1107
DNA
TYPE functioning gene
STRUCTURE 5.41 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure promoter containing motifs seen in other early-response genes
MAPPING cloned Y linked N status provisional
Physical map
EIF2S1 14q21.3 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa PLEK2 14q23.1-q23.2 pleckstrin 2 FLJ33387 14q24.1 hypothetical protein FLJ33387 PIGH 2p21-p16 phosphatidylinositol glycan, class H LOC390490 14 similar to Ac2-008 ARG2 14q24.1-q24.3 arginase, type II VTI1B 14q23,3 vesicle transport through interaction with t-SNAREs homolog 1B (yeast) COX7A3P 14 cytochrome c oxidase subunit VIIa polypeptide 3 pseudogene RDH11 14q23-q24.3 retinol dehydrogenase 11 (all-trans and 9-cis) RPL21P9 14q23.3 ribosomal protein L21 pseudogene 9 RDH12 14q23.3 retinol dehydrogenase 12 (all-trans and 9-cis) ZFYVE26 14q23.2-q24.2 zinc finger, FYVE domain containing 26 RAD51L1 14q24.1 RAD51-like 1 (S. cerevisiae) RPL7AP5 14 ribosomal protein L7a pseudogene 5 RPL12P7 14 ribosomal protein L12 pseudogene 7 ZFP36L1 14q22-q24 zinc finger protein 36, C3H type-like 1 MAGOHP 14 mago-nashi homolog, proliferation-associated pseudogene (Drosophila) BLZF2P 14q24.1 basic leucine zipper nuclear factor 2 pseudogene ACTN1 14q24.1 actinin, alpha 1 RPS29P1 14 ribosomal protein S29 pseudogene 1 WDR22 14q24.1 WD repeat domain 22 DDX18P1 14q21.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene 1 C14orf114 14q24.1 chromosome 14 open reading frame 114 GALNTL1 14q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 ERH 7q34 enhancer of rudimentary homolog (Drosophila) SLC39A9 14q24.1 solute carrier family 39 (zinc transporter), member 9 RPL24P3 14q24.1 ribosomal protein L24 pseudogene 3 C14orf162 14q24.1 chromosome 14 open reading frame 162 LOC387994 14 LOC387994 KIAA0247 14q24.1 LOC387994 SFRS5 14q24 splicing factor, arginine/serine-rich 5 SLC10A1 14q24.1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 SMOC1 14q24.1 SPARC related modular calcium binding 1 RPL7AP6 14 ribosomal protein L7a pseudogene 6 SLC8A3 14q24.1 solute carrier family 8 (sodium-calcium exchanger), member 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3022 - 338 - 2002 12198173
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Hearing/Equilibriumear   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transactivation domains
  • a distinguishing putative zinc finger domain with a repeating cys-his motif (two C3H1-type zinc fingers)
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp36l1
    homolog to C.elegans f38b7.1b
    intraspecies homolog to tristetraprolin
    Homologene
    FAMILY
  • CCCH tandem zinc finger proteins (TTP family)
  • TIS11 family of early response genes
  • tristetraprolin family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text shuttle between the nucleus and cytoplasm
    basic FUNCTION
  • specifying a putative nuclear transcription factor, functioning in regulating the response to growth factors
  • acting as as an essential regulator of ARE-dependent mRNA decay
  • might also be an important player during myogenic differentiation and regeneration, and an important regulator of myogenesis
  • may be an important regulator of VEGF expression
  • modulator of vascular endothelium growth factor (VEGF) mRNA stability, and important role of ZFP36L1 in wound healing
  • role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation
  • negatively regulates erythroid differentiation by directly binding the 3prime untranslated region of STAT5B encoding mRNA
  • effective in repressing a broad spectrum of target mRNAs bearing structurally distinct AREs in tumor cells
  • enhances vascular endothelial growth factor (VEGF) mRNA decay through its interaction with AU-rich elements within VEGF 3prime-untranslated region
  • involved in AU-rich-dependent regulation of mRNA stability/degradation
  • ZFP36L1-mediated mechanism is used by endothelial cells under hypoxia for controlling DLL4 mRNA levels
  • new function in mammalian cell mRNA 3prime-end maturation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text required for apoptosis in Ramos B cells induced through Ca2+ signaling and as a target for IL-4
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • negative regulator of VEGFA gene activity during development
  • interact with AU-rich elements in the 3prime untranslated region of mRNA, which leads to mRNA degradation and translational repression
  • Dll4 is a physiological target of ZFP36L1 (binds to endogenous DLL4 mRNA, and represses mRNA expression without affecting its stability)
  • cell & other
    REGULATION
    induced by various agonists such as the phorbol ester.TPA and the polypetide mitogen EGF
    calcium ionophore
    ACTH
    a broad variety of growth factors and cytokines, and by scratch wounding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    R9-ZFP36L1 may potentially control invasive behavior of aggressive tumors (R9-ZFP36L1 fusion protein may represent a novel antiangiogenic and antitumoral agent)
    ANIMAL & CELL MODELS