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FLASH GENE
Symbol DCD contributors: - updated : 06-01-2006
HGNC name dermcidin
HGNC id 14669
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - ITGA5 - PDE1B - LACRT - DCD - STAT2 - ERBB3 - CDK2 - CDK4 - TSPAN31 - GLI - MDM2 - qter
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainpons  
Reproductivefemale systembreastmammary gland  
Skin/Tegumentskin    
 skin appendagesskin glandsweat glandeccrine sweat gland 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum corneum 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion sweat
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to lacritin
Homologene
FAMILY
CATEGORY regulatory , secretory , protooncogene
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • broad spectrum, antimicrobial peptide, playing a role in the regulation of human skin flora
  • playing a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mn2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS