SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,vesicle
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| being present mainly on the plasma membrane (López-Corcuera 2001) |
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with membrane rafts are co-localized in the membrane, and this influences the rate of glycine transport (Liu 2009) |
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astrocytes express functional SLC6A5, which challenge previous findings that those cells would express only SLC6A9, whereas SLC6A5 was supposed to be restricted to the glycinergic nerve terminals |
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expressed not only at the plasma membrane of glutamatergic neurons, but also at synaptic vesicles |
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is located predominantly on astrocytes |
basic FUNCTION
| Na+ (and Cl-) dependent plasma membrane transporter |
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plays a pivotal role in maintaining the glycine level at the glutamatergic synapse |
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may play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission |
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likely mediating glycine uptake in cortical fiber cells, but not responsible for the accumulation of glycine in the center of the lens |
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most likely mediates glycine transport at the inner blood-retinal barrier and is expected to play an important role in regulating the glycine concentration in the neural retina (Okamoto 2009) |
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regulates both glycinergic and glutamatergic neurotransmission by controlling the reuptake of glycine at synapse (Fernández-Sánchez 2009) |
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plays important role in maintaining accurate glycine concentration in local brain microenvironment |
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glycine transport by SLC6A9 is inhibited by lithium whereas SLC6A5 transport is stimulated, and this effect is more evident at increased glycine concentrations |
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essential role in glycine mediated cytoprotection in intestinal absorptive cells |
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neuronal and glial SLC6A9 may regulate cognitive functions via dissociable mechanisms |
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mainly glial glycine transporter, primarily responsible for the completion of inhibitory neurotransmission |
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SLC6A5, SLC6A9 are the transporters responsible for glycine uptake from the synaptic cleft |
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functional role of SLC6A9 in a subpopulation of glutamatergic vesicles |
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SLC6A5, SLC6A9 are responsible for the termination of glycine-mediated synaptic activity through removal of neurotransmitter from synaptic cleft |
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is essential for the clearance of glycine from the extracellular space and termination of glycinergic neurotransmission |