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FLASH GENE
Symbol SLC44A4 contributors: mct/npt - updated : 13-05-2009
HGNC name solute carrier family 44, member 4
HGNC id 13941
DNA
TYPE functioning gene
STRUCTURE 15.85 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2643 79 710 - O'Regan (2000)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine   
 pancreas exocrine   highly
 pharynx   highly
Reproductivemale systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans F35C8.7
    ortholog to murine Ctl4
    intraspecies homolog to CTL1
    homolog to CTL2
    Homologene
    FAMILY
  • CTL (choline transporter-like) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a choline transporters
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • choline
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion      
    CTL4/Neu1 fusion in sialidosis
    constitutional   deletion    
    in sialidosis
    Susceptibility to late onset Alzheimer disease (Webster 2009)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS