basic FUNCTION
| having a serine/threonine kinase activity |
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may play a role in tumor cell growth and neuronal cell death |
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NF-kappaB-inducible protein, inhibiting AKT1 activity by preventing its phosphorylation |
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involved in a novel negative feedback control pathway of NF-kappaB-induced gene expression |
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may function as a negative feedback regulator of ATF4 |
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novel target of DDIT3/ATF4 and downregulates its own induction by repression of DDIT3/ATF4 functions, and is involved in DDIT3-dependent cell death during ER stress |
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acting as a potent negative regulator of PPARgamma, a master regulator of adipocyte differentiation, and tightly controls adipogenesis |
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key in determining cell fate while responding to environmental challenges |
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protects cells against the growth inhibitory and cytotoxic effect of ATF4 |
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scaffold-like regulator of various signal transducers and has been implicated in several processes including insulin signaling, NF-kappaB signaling, lipid metabolism and BMP signaling |
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stress-inducible protein, and is an unstable protein regulated by the ubiquitin-proteasome system |
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TRIB3 is a regulator for adjusting the expression level of CDC25A both in a normal and a genotoxic conditions |
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is independently associated with poor prognosis of breast cancer patients, possibly through its association with tumor cell hypoxia |
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acts as a novel SMAD3-interacting protein to participate in the positive regulation of TGFB-SMAD-mediated cellular biological functions |
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potent physiological regulator of insulin sensitivity and mitochondrial glucose oxidation under conditions of nutrient deprivation and excess |
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is a stress-inducible nuclear protein, which has recently been shown to be involved in ER stress-induced apoptosis |
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through its own cleavage, functions as a molecular switch between the cell survival and apoptotic pathways under stressful conditions |
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emerges as an important guardian of genome integrity |
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may serve as a negative regulator of pro-inflammatory cytokines and chemokines, controlling the extent of the inflammatory response |
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scaffold protein activated under hypoxic conditions and involved in several cell survival and proliferation pathways |
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pseudokinase implicated in the cellular stress response and has been linked to inflammation in certain situations |
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potential role in the modulation of the immune response |
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TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, are pro-survival modulators of cell viability in nutrient-deficient microenvironments |