basic FUNCTION
| muscle-specific ubiquitin ligase adaptor that regulates myofibril organization |
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function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers |
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developmentally regulated protein that functions as the adaptor component of a RING-type ubiquitin ligase complex specific to striated muscle |
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substrate-binding component of the muscle-specific ubiquitin ligase complex NEURL2-E3 |
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plays an active role in myofiber differentiation and maturation, during embryogenesis and muscle regeneration |
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having distinct functions to maintain the integrity of at least two cell compartments, containing actin filaments, the sarcolemmal-associated cortical cytoskeleton and the sarcomere |
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may exert a dual function toward PDCD6IP, modulating its conformation and ubiquitination status |