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FLASH GENE
Symbol NEURL2 contributors: mct - updated : 28-01-2014
HGNC name neuralized-like 2 (Drosophila)
HGNC id 16156
DNA
TYPE functioning gene
STRUCTURE 2.82 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1440 - 285 - -
2 - 1454 - 261 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiensFetal
 brainlimbic systemhippocampus   Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
SOCS box (suppressor of cytokine signaling)
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane,junction
    intracellular
intracellular,cytoplasm
text
  • has a predominantly cytoplasmic localization
  • basic FUNCTION
  • muscle-specific ubiquitin ligase adaptor that regulates myofibril organization
  • function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers
  • developmentally regulated protein that functions as the adaptor component of a RING-type ubiquitin ligase complex specific to striated muscle
  • substrate-binding component of the muscle-specific ubiquitin ligase complex NEURL2-E3
  • plays an active role in myofiber differentiation and maturation, during embryogenesis and muscle regeneration
  • having distinct functions to maintain the integrity of at least two cell compartments, containing actin filaments, the sarcolemmal-associated cortical cytoskeleton and the sarcomere
  • may exert a dual function toward PDCD6IP, modulating its conformation and ubiquitination status
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with Notch ligands DLL1 and JAG1
  • NEURL and NEURL2 interact with another Notch ligand, DLL4
  • interacts with and regulates myosin within its fully assembled cytoskeletal structure
  • NEURL2 ligase regulates PDCD6IP at sites where the actin cytoskeleton undergoes remodeling
  • PDCD6IP is a bona fide interacting partner of NEURL2 and interaction between the two native proteins occurs in the differentiated muscle fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS