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FLASH GENE
Symbol TUBA1B contributors: - updated : 31-08-2007
HGNC name tubulin, alpha 1b
HGNC id 18809
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 3.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunetonsils   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix predominantly
Respiratorylung   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to Drosohila tub84b
homolog to C.elegans tba-2
homolog to rattus T26
intraspecies paralog to TUBA3
paralog to TUBA6
Homologene
FAMILY alpha tubulin gene family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
text polymerizes to form microtubules
basic FUNCTION unknown
CELLULAR PROCESS cell organization/biogenesis
PHYSIOLOGICAL PROCESS
text cell structure
PATHWAY
metabolism
signaling
a component
  • part of a heterodimer polymerizing to form microtubules
  • major constituent of microtubules
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP (binding two moles of GTP, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain)
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS