Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TUBA1B contributors: mct - updated : 02-02-2022
HGNC name tubulin, alpha 1b
HGNC id 18809
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 3.61 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1627 - 451 - 2020 32908931
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunetonsils   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix predominantly
Respiratorylung   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to Drosohila tub84b
homolog to C.elegans tba-2
homolog to rattus T26
intraspecies paralog to TUBA3
paralog to TUBA6
Homologene
FAMILY alpha tubulin gene family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
text polymerizes to form microtubules
basic FUNCTION
  • CCNE1/REL and TUBA1B/ESR1 might play pivotal roles in the occurrence and development of Postmenopausal osteoporosis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell structure
    PATHWAY
    metabolism
    signaling
    a component
  • part of a heterodimer polymerizing to form microtubules
  • major constituent of microtubules
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP (binding two moles of GTP, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain)
    protein
  • TUBA1B and TUBB3, were identified as the novel CLDN11-interacting proteins, and CLDN11 interacted with these two tubulins through its intracellular loop and C-terminus
  • coexpressed genes of TUBA1B were enriched in the pathway of DNA replication, mismatch repair, cell cycle, pathogenic Escherichia coli infection, and spliceosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral       gain of function
    in Wilms' tumor (WT) tissues
    tumoral     --over  
    higher expressed in Hepatocellular carcinoma (HCC)tumor tissues than in adjacent nontumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • increased TUBA1B expression was associated with poor overall survival and resistance to paclitaxel of HCC patients
  • Therapy target
    ANIMAL & CELL MODELS