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FLASH GENE
Symbol TCF25 contributors: mct - updated : 27-02-2008
HGNC name transcription factor 25 (basic helix-loop-helix)
HGNC id 29181
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 37.00 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2267 76 676 - Steen (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunetonsils   highly
Nervousbrain   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bHLH domain that is found in proteins active in gene transcription
  • a DUF654 domain in the c-terminal part of the molecule
  • HOMOLOGY
    Homologene
    FAMILY
  • basic helix-loop-helix (bHLH) proteins family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • plays a role in cell death control and may influence tumor growth
  • acting as a transcriptional repressor in serum response factor (SRF)-mediated gene regulation
  • may have a distinct role in embryonic development of many organs, including the adult brain
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds the X-linked inhibitor of apoptosis protein (XIAP) and this interaction was increased during cell death
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induces cell death of osteosarcoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target better therapies to treat tumors as osteosarcoma
    ANIMAL & CELL MODELS