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FLASH GENE
Symbol HOPX contributors: mct/npt/pgu - updated : 18-09-2009
HGNC name HOP homeobox
HGNC id 24961
DNA
TYPE functioning gene
STRUCTURE 33.72 kb     3 Exon(s)
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two putative promoters (promoters A and B) associated with two open reading frames (HOPalpha and HOPbeta, respectively) (PMID:18234960)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1552 - 91 down-regulated in in esophageal squamous cell carcinoma independently of HOPbeta 2007 17576768
  • HOPalpha
  • 3 - 1154 - 73 down-regulated in in esophageal squamous cell carcinoma independently of HOPalpha 2007 17576768
  • HOPbeta
  • 3 - 1427 - 73 - 2007 17576768
    3 - 1198 - 73 - 2007 17576768
    5 - 1682 - 112 - 2007 17576768
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart   highly
    Digestiveintestine    
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    digestiveheartmyocardium  
    Lymphoid    
    Muscularsmooth   
    Muscularstriatum   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text heart, neural tube, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix motif
  • a putative homeobox domain
  • forms a classical homeodomain fold but that it cannot recognize double stranded DNA
  • secondary structure three alpha helices with a helix-turn-helix characteristic of the homeodomain
    HOMOLOGY
    interspecies homolog to rattus Hod
    homolog to murine Hod
    intraspecies homolog to HOX6
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • unusual homeodomain protein modulating SRF-dependent, cardiac specific gene expression and cardiac development
  • involved in directing villous morphogenesis and regulation of proliferation and invasiveness
  • acts downstream of NKX2-5 and associates with the serum response factor (SRF), repressing transcription from SRF-responsive genes
  • is also able to recruit histone deacetylase (HDAC) activity, consistent with its ability to repress transcription
  • may functions as an adaptor protein to mediate transcriptional repression
  • potential tumor suppressor possibly involved in lung cancer differentiation, and functions downstream of NKX2-1
  • critical role in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease
  • putative tumor suppressor gene that harbors tumor inhibitory activity
  • modifies the expression of cardiac-specific genes and thereby regulates heart development
  • CDK5R1, HOPX, FKBP4, SGTA proteins plays a distinct role in the steroid hormone receptor regulatory cycle
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS cardiovascular , development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SRF
  • NKX2-5
  • cell & other
    REGULATION
    Other regulated by NKX2-5
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer in development and progression
    tumoral     --low  
    from hypermethylation of the promoter, which leads to endometrial cancer development
    tumoral        
    by promoter DNA hypermethylation in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS