basic FUNCTION
| unusual homeodomain protein modulating SRF-dependent, cardiac specific gene expression and cardiac development |
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involved in directing villous morphogenesis and regulation of proliferation and invasiveness |
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acts downstream of NKX2-5 and associates with the serum response factor (SRF), repressing transcription from SRF-responsive genes |
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is also able to recruit histone deacetylase (HDAC) activity, consistent with its ability to repress transcription |
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may functions as an adaptor protein to mediate transcriptional repression |
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potential tumor suppressor possibly involved in lung cancer differentiation, and functions downstream of NKX2-1 |
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critical role in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease |
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putative tumor suppressor gene that harbors tumor inhibitory activity |
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modifies the expression of cardiac-specific genes and thereby regulates heart development |
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CDK5R1, HOPX, FKBP4, SGTA proteins plays a distinct role in the steroid hormone receptor regulatory cycle |