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FLASH GENE
Symbol BCAR3 contributors: mct - updated : 22-06-2016
HGNC name breast cancer anti-estrogen resistance 3
HGNC id 973
DNA
TYPE functioning gene
STRUCTURE 120.03 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
TRAP2 1p22 tumor rejection antigen (gp96) pseudogene 2 TGFBR3 1p33-p32 transforming growth factor, beta receptor III (betaglycan, 300kDa) BRDT 1p21-p22 bromodomain, testis-specific ABHD7 1p22.1 abhydrolase domain containing 7 LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23 M96 1p22.1 likely ortholog of mouse metal response element binding transcription factor 2 CGI-100 1pter-q31.3 CGI-100 protein NY-SAR-41 1p22.1 sarcoma antigen NY-SAR-41 DR1 1p22.1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) FLJ20275 BCAR3 1p22.1 breast cancer anti-estrogen resistance 3 LOC388651 1 LOC388651 HSU15552 1p22.1 acidic 82 kDa protein mRNA GCLM 1p22.1 glutamate-cysteine ligase, modifier subunit ABCA4 1p22.1 ATP-binding cassette, sub-family A (ABC1), member 4 PARG1 1p22.1 PTPL1-associated RhoGAP 1 LOC391057 1 similar to uracil DNA glycosylase ABCD3 1p22.1-p21.3 ATP-binding cassette, sub-family D (ALD), member 3 F3 1p22.1-p21 coagulation factor III (thromboplastin, tissue factor) MGC45474 1p22.1 hypothetical protein MGC45474 CNN3 1p21 calponin 3, acidic MGC19780 1p22.1 hypothetical protein MGC19780 FLJ31842 1p22.1 hypothetical protein FLJ31842 RWDD3 1p22.1 RWD domain containing 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3184 - 825 - 2007 17270363
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   moderately
 mouthtongue  moderately
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative SRC homology 2 (SH2) domain, interacting with Tyr789 of PTPRA, interaction required for PTPRA-BCAR3-PTPR1-SRC interaction and promotes the integrin-induced movement of BCAR3 and BCAR1 to focal adhesion-enriched fractions
  • a Ras-GEF domain, that binds to BCAR1
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Bcar3 (85.9 pc)
    homolog to murine Bcar3 (86.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulating cell growth and apoptosis in hormone-sensitive cells
  • may act as an adaptor protein
  • coupling activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells
  • acting as a guanyl-nucleotide exchange factor
  • involved in reponse to drug
  • implicated in the regulation of cell morphology, adhesion and migration
  • regulating SRC activity in the endogenous setting of breast cancer cells (Schuh 2010)
  • regulating the interaction between BCAR1 and SRC, qualitatively and quantitatively (Schuh 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • small GTPase mediated signal transduction
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAR1, NEDD9, PTK2 and PTPN1
  • is an activator of SRC and is a molecular linker of PTPRA and BCAR1 (
  • BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not SLC2A4 translocation
  • cell & other
    REGULATION
    Other regulated by cellular adhesion to extracellular matrix proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    confering anti-estrogen resistance in breast cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS