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FLASH GENE
Symbol CAMTA2 contributors: - updated : 05-07-2006
HGNC name calmodulin binding transcription activator 2
HGNC id 18807
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text
  • alternatively spliced transcript variants have been identified, but their full-length natures have not been determined
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   moderately
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivemale systemprostate  moderately
    Urinarybladder   moderately
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an IPT/TIG domain
  • three ankyrin repeats (ANK)
  • two IQ calmodulin-binding motifs
  • a type of DNA-binding domain (CG-1 domain)
  • a bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies ortholog to rattus Camta2 (92.7pc)
    ortholog to murine Camta2 (92.6pc)
    Homologene
    FAMILY
  • calmodulin-binding transcription activator (CAMTA) protein family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • promoting cardiomyocyte hypertrophy
  • activating the atrial natriuretic factor (ANF) gene
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text
  • transcription activator
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calmodulin in the presence of calcium
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS