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FLASH GENE
Symbol IFI44L contributors: mct - updated : 13-03-2023
HGNC name interferon-induced protein 44-like
HGNC id 17817
DNA
TYPE functioning gene
STRUCTURE 25.70 kb     9 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • two IFN-stimulated response elements (ISRE), which are necessary for the basal level of IFI44L transcription
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 5857 - 452 - 2014 24755989
    9 - 5369 - 194 - 2014 24755989
    9 - 5829 - 452 - 2014 24755989
    8 - 5341 - 194 - 2014 24755989
    7 - 5145 - 194 - 2014 24755989
    6 - 5096 - 194 - 2014 24755989
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a ATP/GTP-binding site motif A (P-loop) domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • expression of IFI44L was increased in viral patients and FAM89A was increased in bacterial patients relative to healthy children
  • role of IFI44L in the antiviral innate immune response
  • involved in innate immune processes and act as a tumor suppressor in several cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP/GTP
    protein
  • STAT3 regulated IFI44L expression and interacted with TET2 which induced DNA demethylation of IFI44L promoter
  • cell & other
    REGULATION
    induced by induced by IFN and HIV-1 infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in systemic lupus erythematosus (SLE) monocyte
    constitutional     --over  
    by IFI44L promoter demethylation from whole peripheral blood in Iranian SLE patients(methylation significantly lower than healthy controls)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for non-small cell lung cancer patients
  • significant hypomethylation of two CpG sites within IFI44L promoter, was identified in patients with SLE
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    IFI44L is expected to become a new target for treatment of SLE
    ANIMAL & CELL MODELS