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FLASH GENE
Symbol AHSA1 contributors: - updated : 15-12-2006
HGNC name AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
HGNC id 1189
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrineadrenal gland    
 placenta    
Nervousbraindiencephalonhypothalamus  
 brainforebraincerebral lobefrontal 
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to chimpanzee AHSA1 (99.7pc)
homolog to murine Ahsa1 (95.0pc)
homolog to chicken AHSA1 (77.2pc)
Homologene
FAMILY AHA1 family
CATEGORY chaperone/stress , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • affecting cargo movement at the step of ER to Golgi traffic
  • activating the ATPase activity of HSP90 and modulating the stability of CFTR
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to VSVG (vesicular stomatitis virus glycoprotein)
  • interacting with HSP90
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS