SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
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| intracellular,nucleus
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| after epidermal growth factor (EGF) stimulation, colocalizes with EGF receptor (EGFR) on endosomes, which requires both its N- and C-terminal extension sequences |
basic FUNCTION
| activating PAK1 and JNK1 |
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inducing filopodium formation and stress fiber dissolution |
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mediating the effects of WNT1 signaling in the regulation of cell morphology, cytoskeleton organization and cell proliferation |
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involved in chromosome alignment during mitosis of HeLa cells |
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implicated in Wnt signaling, regulation of the cytoskeleton and cell proliferation |
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only RhoGTPase whose expression is induced by TNFSF11 during osteoclastogenesis |
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act on the actin cytoskeleton by stimulating filopodia formation and stress fibre dissolution |
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also involved in the regulation of cell:cell contacts in a PAR6-dependent manner |
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essential regulator of cranial neural crest cell migration |
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unique regulatory mechanism by which RHOU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RHOU activation |
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atypical Rho GTPase, that link WNT1 to downstream responses, such as cell transformation and gene transcription |
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its activity maintains the epithelial architecture of the endoderm progenitors, and its downregulation accompanies the transition of the columnar epithelium in the embryonic foregut to a multilayered cell sheet during organ formation |