basic FUNCTION
| may be involved in cell cycle and apoptosis regulation during neurogenesis |
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involved in the regulation of chromosome condensation and neurodevelopment |
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role in the DNA damage response |
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acts as a regulator of both the intra-S and G2/M checkpoints |
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has a crucial role in the DNA damage response by promoting the expression of Checkpoint kinase 1 (CHEK1) and BRCA1 through the interaction with E2F1 on the promoters of both genes |
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a proximal factor in the DNA damage response pathway |
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a crucial DNA damage regulator in the ATM/ATR pathways potential and acts as a tumor suppressor gene |
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MCPH1 and PCNT regulate mitotic entry |
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via centrosome-associated CHEK1 |
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can regulate the telomeric DNA-damage response |
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regulator of ATP-dependent chromatin remodelling complex SWI/SNF in DBA repair |
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essential roles in mitotic and meiotic recombination DNA repair and in maintaining genomic stability |
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controls centrosome numbers after DNA damage, which may indicate a novel tumour suppressive mechanism for microcephalin |
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important regulator of chromosome condensation/decondensation and disruption of the MCPH1-SET interaction might be important for the pathogenesis of primary microcephaly |
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acts as a composite modulator of condensin II to regulate chromosome condensation and shaping |
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required for precise mitotic spindle orientation and regulates the progenitor division mode to maintain brain size |
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crucial gene in the complex cellular machine that is devoted to DNA repair and acts as a regulator of both the intra-S and G2/M checkpoints |
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implicated in various cellular processes including the DNA damage checkpoint, DNA repair, and transcription |
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ensures proper neuroprogenitor expansion and differentiation through its function in the centrosome, and in the DNA damage response |