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FLASH GENE
Symbol LAYN contributors: - updated : 10-10-2006
HGNC name layilin
HGNC id 29471
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Nervousbrain    
 nervecranial nerve  highly
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to chimpanzee LAYN (98.9pc)
homolog to murine Layn (82.5pc)
intraspecies homolog to MT75 (CHODL)
Homologene
FAMILY
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • having a hyaluronan receptor activity
  • may have a role in cell adhesion and motility
  • may mediate signals from extracellular matrix to the cell cytoskeleton via interaction with different intracellular binding partners and thereby be involved in the modulation of cortical structures in the cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to talin
  • interacting with merlin and radixin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS