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FLASH GENE
Symbol EPN1 contributors: mct/npt - updated : 27-04-2012
HGNC name epsin 1
HGNC id 21604
DNA
TYPE functioning gene
STRUCTURE 20.57 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2964 - 662 - 2003 12750376
11 - 2501 - 576 - 2003 12750376
10 - 2423 - 550 - 2003 12750376
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousnerve   highly
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins) , and contains an additional N-terminal hydrophobic alpha0 helix
  • two or three ubiquitin-interacting motifs (UIMs)
  • two clathrin binding sequences
  • several AP2-binding sites
  • several Eps15 homology (EH) domain binding motif, that function in vesicular trafficking and endocytosis
  • three Arg-Pro-Phe (NPF) motifs in the C terminal region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Epn1
    Homologene
    FAMILY
  • epsin family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • accumulated at synaptic coated pits
  • within the synaptic compartments, distributed similarly throughout
  • basic FUNCTION
  • playing a role in clathrin-mediated endocytosis of synaptic vesicles
  • may act as an alternate adaptor in several endocytic pathways
  • involved in clathrin-mediated synaptic vesicle endocytosis (an additional mechanism for generation of uniformly sized synaptic vesicles)
  • EPN1 and huntingtin-interacting protein 1 (HIP1) are endocytic accessory proteins (
  • EPN1 and HIP1 in the synapse: as broadly required factors for promoting clathrin assembly and as adaptors for specific endocytic pathways
  • participatong in clathrin-mediated synaptic vesicle endocytosis at a central synapse
  • promotes endocytosis of the ubiquitinated EGFR
  • endocytic adaptor with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins
  • role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling
  • endocytic adapter protein, regulating mitotic membrane morphology and spindle integrity
  • epsin-induced membrane curvature is required for proper spindle morphogenesis, independent of its function in endocytosis during interphase
  • adaptor protein complex-2 and EPN1 are both critical mediators of agonist-stimulated F2R internalization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • coat component in several clathrin-mediated endocytic pathways
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to AP-2
  • binding to EPS15
  • binding to POB1 (to the EH domain)
  • interacted with ubiquitinated EGFR and functional UIMs were essential for complex formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS