basic FUNCTION
| having GTPase activator activity |
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acting as a tumor suppressor |
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suppresses Ras signaling and Ras-induced cellular transformation (Kawai 2009) |
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with DLC1 share the same molecular mechanism in targeting to focal adhesions (Kawai 2009) |
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modulating angiogenic responses in vascular endothelial cells by regulating cell attachment and migration (Lin 2010) |
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plays a key role in pain modulation during inflammation by suppressing the activation of RHOA and ERK to prevent an exaggerated pain response |
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STARD13 plays a role of a tumor suppressor in astrocytoma |
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is an essential regulator of pancreas tissue architecture in the mammalian embryo |
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acts by regulating RHO signalling spatially and temporally during pancreas development |
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Rho GTPase and its regulator, STARD13 RhoGAP, coordinate morphogenesis with growth in the developing pancreas |
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role of STARD13 as a tumor suppressor as well as a RHO GAP |
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is a tumor suppressor in breast cancer that regulates cell motility and invasion |
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STARD13 and KIF1B are thus central components of a signalling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity |