basic FUNCTION
| involved in chromatin binding |
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required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis |
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involved in chromosome condensation depending on the ability of ASF1A to physically interact with its deposition substrate, histone H3, in addition to its cochaperone, HIRA |
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with ASF1B play a role in the efficiency of nucleosome assembly in vivo in human cells (Galvani 2008) |
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Histone H3/H4 chaperone, target for cell-cycle regulated Tousled-like kinases (TLKs) and both proteins cooperate during chromatin replication (Pilyugin 2009) |
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highly conserved histone H3/H4 chaperone that synergizes with two other histone chaperones, CHAF1A and HIRA, in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly |
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HIRA and ASF1A, play an important role in muscle differentiation by facilitating MYOD1 expression |
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one of its critical biological functions involves activity in the transcription initiation step (Akai 2010) |
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is a histone chaperone that participates in chromatin higher-order organization and is required for appropriate chromatin assembly |
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depletion of ASF1A produces a recovery defect, and both TLK2 and ASF1A are required to restore histone H3 incorporation into damaged chromatin |