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FLASH GENE
Symbol ACTR2 contributors: mct - updated : 09-07-2019
HGNC name ARP2 actin-related protein 2 homolog (yeast)
HGNC id 169
DNA
TYPE functioning gene
STRUCTURE 42.56 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D2S2397 - D2S1342 - ACTR2 - D2S2231 - D2S380 - cen
Physical map
OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a HSPC159 2p15 HSPC159 protein FLJ20080 2p15 hypothetical protein FLJ20080 TRIP-Br2 2p15 transcriptional regulator interacting with the PHS-bromodomain 2 SLC1A4 2p13.3 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 LOC200731 2p14 hypothetical LOC200731 KIAA0582 2p14 hypothetical LOC200731 RAB1A 2p14 RAB1A, member RAS oncogene family LOC150984 2p14 similar to voltage-dependent anion channel isoform 2 ACTR2 2p14 ARP2 actin-related protein 2 homolog (yeast) SPRED2 2p14 sprouty-related, EVH1 domain containing 2 LOC388956 2 LOC388956 LOC391379 2 similar to DnaJ homolog subfamily B member 12 LOC391380 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 ETAA16 2p13-p15 ETAA16 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 3929 - 394 - -
10 splicing 3944 - 399 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
interspecies homolog to Drosophila Arp14D
homolog to C.elegans K17C5.1
ortholog to Actr2, Mus musculus
homolog to yeast S.cerevisiae arp2
ortholog to Actr2, Rattus norvegicus
ortholog to ACTR2, Pan troglodytes
Homologene
FAMILY
  • actin family
  • ARP2 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text actin cytoskeleton associated
    basic FUNCTION
  • being essential to cell shape and motility through lamellipodial actin assembly and protrusion
  • ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
  • close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
  • WASF2–ACTR2/ACTR3 is necessary for myosin II recruitment and tension generation at the zonula adherens
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major constituent of the Arp2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS