SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,nucleus
|
| intracellular,nuclear envelope,int
|
text
| nuclear and perinuclear (integral membrane protein located at the inner nuclear membrane) |
|
SUN1 and LMNA colocalize at the Nuclear Envelope (NE) |
|
SUN1 deleted for Its N-Terminal Lamin A-Interacting Domain Locates in the Golgi |
|
inner nuclear membrane (INM)2 proteins playing a major role in nuclear-cytoplasmic connection by formation of a bridge across the nuclear envelope (NE), known as the LINC complex |
basic FUNCTION
| involved in acetylation of histones for de-compacting DNA at the end of mitosis |
|
connects the nucleoplasm with the cytoskeleton |
|
SYNE2, and SUN1, SUN2 mediate nuclear migration of the photoreceptor cells through bridging microtubules with molecular motors to the nuclei |
|
SYNE2 and SUN1 are involved in an early retinal developmental stage and the loss of function of these proteins eventually leads to an increase in cell death linked to apoptosis |
|
nuclear envelope protein involved in nuclear migration, meiotic telomere tethering, and antiviral responses ( |
|
major role of SUN1 and SUN2 in the nucleo-cytoskeleton interactions and in regulation of nuclear positioning in differentiating cells |
|
SUN1 and SUN2 may play a redundant role in DNA damage response (DDR) |
|
SUN1 and SUN2 could affect DDR by localizing certain nuclear factors to the nuclear enveloppe or by mediating communication between nuclear and cytoplasmic events |
|
role of SUN1, SUN2 proteins in bipolar spindle assembly and mitotic progression |
|
important role for SUN1 and SUN2 in muscle disease pathogenesis which support the hypothesis that defects in the LINC complex contribute to disease pathology through disruption of nuclear-microtubule association, resulting in defective myonuclear positioning |
|
mitotic phosphorylation of SUN1 disrupts interactions with nucleoplasmic binding partners, promoting disassembly of the nuclear lamina and, potentially, its chromatin interactions |
|
inner nuclear envelope protein SUN1 has additional functions aside from being a central component of the LINC complex and it is an integral component of the mammalian mRNA export pathway |
|
SUN1 is involved in the HIV-1 nuclear entry process |
|
SUN1 modulates gene expression independently of its incorporation into LINC complexes |
|
is required for efficient muscle regeneration |
|
SUN1, SUN2, SYNE1 (LINC complex) have emerged as a key regulators of actin cytoskeletal organisation |
|
LINC complex exists in a mechanical feedback circuit with RHOA to regulate Vascular smooth muscle cells (VSMCs) actomyosin activity and morphology |
|
mislocalization of LINC complex proteins (SUN1, SUN2, LMNA, EMD, SYNE1) is a significant characteristic of cellular senescence phenotypes and may influence complex events at the nuclear membrane, including trafficking and heterochromatin attachment |