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FLASH GENE
Symbol SLC9A3R2 contributors: mct - updated : 08-09-2015
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
HGNC id 11076
DNA
TYPE functioning gene
STRUCTURE 11.55 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2159 - 326 - 2007 17229887
7 - 2192 - 337 - 2007 17229887
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly Homo sapiens
Nervousbrain     Homo sapiens
Respiratorylung   highly Homo sapiens
Urinarykidneytubuleconvoluted tubule   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Nervousastrocyte Homo sapiens
Urinaryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two highly conserved domains PDZ, two PSD-95/Dlg/ZO-1 (PDZ) domains and the second interacts with a PDZ-binding motif at the very carboxy terminus of beta-catenin
  • slow mobility rate of SLC9A3R2 was determined by a unique C-terminal domain, which includes a nonconserved region along with the ezrin, radixin, moesin (ERM) binding domain
  • mono polymer oligo
    HOMOLOGY
    interspecies homolog to murine Slc9a3r2
    intraspecies homolog to SLC93R1
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • predominantly localized near the actin cytoskeleton, thus poising them near the plasma membrane where they function as scaffold
  • localized to the brush border in kidney and intestinal epithelial cells
  • co-localized with SLC1A3 in ER–Golgi intermediate compartments (ERGICs), at the plasma membrane and in early endosomes, but not in the ER
  • basic FUNCTION
  • PDZ-domain containing scaffold protein, involved in SGK dependent TRPV6 regulation
  • key adaptor protein involved in the anchoring of ion channels and receptors to the actin cytoskeleton through binding to ERM (ezrin/radixin/moesin) proteins
  • SLC9A3R1, SLC9A3R2, and PDZK1, modulate CFTR membrane retention, conductivity, and interactions with other transporters
  • determines the coupling of P2RY1 GRM5 to different ion channels in neurons
  • essential to connect ATP2B isoform W/B to ezrin
  • is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling
  • is potentially involved in the endocytosis of SLC1A3
  • roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells
  • essential role in endothelial cell adhesion/migration and angiogenesis
  • coactivator of ESR1 that may participate in the development of estrogen-dependent breast cancer tumors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHR1 (through a PDZ domain interaction)
  • binding partner for the cadherin-associated protein, beta-catenin
  • interacting with GRM5 through its second PDZ domain (can selectively modulate GRM5 signaling, which may contribute to cell-specific regulation of GRM5 activity)
  • interacting with MCC
  • bind to P2RY1, and GRM5 through its PDZ domain
  • competes with SLC9A3R2 to negatively regulate LPA2 receptor signaling in colon cancer cells
  • acts synergistically with WNK4 by stabilizing TRPV5 at the plasma membrane to maintain the positive regulation of WNK4 on TRPV5
  • cAMP-dependent inhibition of SLC9A3 activity requires either SLC9A3R1 or SLC9A3R2
  • SLC9A3R1 and SLC9A3R2 are SCARB1 protein binding partners that play a negative role in the regulation of SCARB1 expression, selective CE (cholesteryl ester) transport, and steroidogenesis
  • SLC9A3R1 interacts with SLC1A3 during ER export, while SLC9A3R2 interacts with SLC1A3 in the secretory pathway from the ERGIC to the plasma membrane, thereby modulating the cell surface expression of SLC1A3
  • PDZ-mediated interaction of SLC9A3R2 and LPAR2, a cellular event implicated in CFTR channel regulation
  • ESR1-associated coactivator that interacts predominantly with the AF1 domain of the nuclear receptor
  • SLC9A3R1, SLC9A3R2 down-regulated SCARB1 at least in part via the ubiquitin/proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS