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FLASH GENE

Symbol

RAB3IP

contributors: npt/mct - updated : 17-06-2016

HGNC name	RAB3A interacting protein (rabin3)
HGNC id	16508

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	84.80 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022456 11 - 9517 NP_071901 51 460 - 2002 12007189 RAB3IP-A1 NM_175623 11 - 9651 NP_783322 - 476 - 2002 12007189 RAB3IP-A2 NM_175624 10 - 9417 NP_783323 - 395 - 2002 12007189 RAB3IP-B1 NM_175625 10 - 9551 NP_783324 - 411 - 2002 12007189 RAB3IP-B2 RAB3IP-G1 - - - - 304 - 2002 12007189 RAB3IP-G2 - - - - 320 - 2002 12007189

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, thymus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one ER retention motif
	one coiled-coil domain
	one nuclear localization signal (NLS)
	the GEF domain RAB3IP display the minimal targeting machinery for recruiting their cognate RABs (RAB1A and RAB8A, respectively) to the mitochondrial membrane

HOMOLOGY

interspecies

homolog to rattus Rabin3

Homologene

FAMILY

SEC2 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	localized to the cortical actin (Hattula 2002)

basic FUNCTION	involved in mediating polarized membrane transport (Hattula 2005)
	having exchange activity on RAB8A and RAB8B but not on RAB3A (Hattula 2002)
	Rab8-specific activator that is connected to processes that mediate polarized membrane traffic to dynamic cell surface structures (Hattula 2002)
	is a direct phospho-substrate of ERK1/2 in response to EGF signaling, and ERK1/2 activate RAB3IP to regulate vesicular trafficking to the plasma membrane in response to extracellular signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes

INTERACTION

DNA

RNA

small molecule

protein	SSX2
	bind RAB8A and function as nucleotide exchange factors for Rab8 but not for RAB3A and RAB5 (Hattula 2005)
	ASAP1 serves as a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein ARF4 and the two G proteins of the Rab family--RAB11A and RAB8A--linked by the RAB8A guanine nucleotide exchange factor RAB3IP
	components of the vesicular transport machinery, the GEF RAB3IP and the GTPase RAB8A, are interacting partners of CEP164
	RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
	RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS