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FLASH GENE
Symbol VTI1B contributors: mct - updated : 28-04-2012
HGNC name vesicle transport through interaction with t-SNAREs homolog 1B (yeast)
HGNC id 17793
DNA
TYPE functioning gene
STRUCTURE 23.73 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1357 - 232 - 2001 12067063
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage
cell lines SV40 transformed fibroblasts clone
fluid/secretion
at STAGE
physiological period ageing
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helical region found in SNAREs
  • HOMOLOGY
    Homologene
    FAMILY
  • VTI1 family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane protein type 4
    basic FUNCTION
  • vesicle docking
  • both VTI1B and STX6 function and have rate-limiting roles in TNFalpha trafficking and secretion
  • combinational SNARE proteins VAMP8 and VTI1B mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation
  • VTI1A, VTI1B, are involved in neuronal development
  • functions at late endosomes
  • CELLULAR PROCESS cell life, senescence
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be concerned with increased secretion of extracellular matrix and various cytokines associated with cellular senescence
    PATHWAY
    metabolism
    signaling
    a component
  • forms a snare complex with syntaxin 7, syntaxin 8 and endobrevin/VAMP-8 which functions in the homotypic fusion of late endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLINT1 binds to VTI1B, suggesting that it may be a VTI1B-selective adaptor
  • endosomal SNARE proteins physically and functionally interact with CFTR
  • interacting with STX11 (by regulating the availability of VTI1B, STX11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS