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FLASH GENE
Symbol MORF4L1 contributors: mct/npt/pgu - updated : 31-01-2017
HGNC name mortality factor 4 like 1
HGNC id 16989
DNA
TYPE functioning gene
STRUCTURE 24.96 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1894 37.1 323 - 2012 22728643
13 - 2011 41.3 362 - 2012 22728643
10 - 1799 - 235 - 2012 22728643
12 - 1847 - 235 - 2012 22728643
- - 1747 - 235 - 2012 22728643
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Nervousnervecranial nerve  highly
Skin/Tegumentskin   highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text pharyngeal arch, fetal cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative chromo domain in the N-terminal part that has been shown to participate in chromatin remodeling and transcription regulation (may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains)
  • chromatin organization modifier domain
  • MRG domain responsible for transcriptional regulation via chromatin remodeling by histone acetylation
  • C-terminal part forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein MRFAP1 during transcriptional regulation
  • HOMOLOGY
    interspecies homolog to yeast Eaf3
    Homologene
    FAMILY
  • mortality family of transcription factors
  • chromodomain superfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    text
  • MORF4L1, MORF4L2 proteins localize predominantly to the chromatin fraction in the nucleus, although a small amount of both proteins localized to the nuclear matrix
  • basic FUNCTION
  • playing a role in transcriptional regulation via chromatin remodeling by histone acetylation
  • having an essential role in embryonic development via chromatin remodeling and transcriptional regulation
  • transcription factor that plays a vital role in embryonic development, cell proliferation and cellular senescence
  • conserved chromodomain protein that associates with histone deacetylases (HDACs) and Tip60-containing histone acetyltransferase (HAT) complexes
  • plays a role in both transcriptional silencing and activation
  • mediates DNA-damage-response functions of the BRCA complex in chromatin
  • member of the BRCA multiprotein complex, essential for the maintenance of the genome integrity and DNA repair
  • is acting in a histone acetylation complex involving KAT5 to modify chromatin via acetylation of histone H4 at the CDC2 promoter to activate transcription
  • contributes likely to the regulation of cell genesis in the retina
  • maintenance of interphase chromosome compaction and homolog pairing status requires both MORF4L1 and TMPRSS4
  • chromodomain-containing chromatin-binding protein, recruiting diverse chromatin-associated complexes that regulate gene transcription, DNA repair, and RNA splicing
  • multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells
  • is essential for pre-mRNA splicing during spermatogenesis and epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorders underlying male infertile patients
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of an MORF4L1/PHF12/SIN3A complex may be implicated in the unique functions of MORF4L1
  • complex containing the corepressor SIN3B, HDAC1, MORF4L1 and PHF12 plays important roles in regulation of transcription
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with at least two nucleoprotein complexes that include histone acetyltransferases and/or histone deacetylases
  • MORF4L1 and MORF4L2 proteins are MRGBP-associating proteins
  • MORF4L1, MORF4L2 associate with RB1 in nucleoprotein complexes and regulate MYBL2 promoter activity (
  • interacting with RBP2 (associated with MORF4L1 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state)
  • PALB2-associated protein that ensures regulated recombination events (abrogation of the PALB2-MORF4L1 interaction resulted in elevated sister chromatid exchange frequencies)
  • PALB2 binds directly to a conserved chromodomain protein, MORF4L1, which is a component of histone acetyltransferase-deacetylase complexes
  • MRFAP1 may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation
  • PHF12 associates with a chromatin interacting protein complex comprised of MORF4L1, SIN3B, and HDAC1, that functions as a transcriptional modulator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    MORF4L1 deficient neural stem/progenitor cell (NSC) exhibit severe defects in DNA damage response following ionizing radiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS