Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GAGE1 contributors: mct/npt - updated : 09-12-2009
HGNC name G antigen 1
HGNC id 4098
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 7.34 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure containing a 143 bp insertion, located in the coding sequence near the termination codon (that is absent from the other of the GAGE family)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 953 15.5 139 - Gjerstorff (2007)
5 - 810 13 117 - Gjerstorff (2007)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
Text in fetal and adult oocyte (Gjerstorff 2007)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • antigenic peptide YRPRPRRY
  • HOMOLOGY
    interspecies homolog to C.elegans r09a8.4
    intraspecies homolog to GAGE family
    Homologene
    FAMILY
  • GAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • recognized on melanoma by autologous cytolytic T lymphocytes
  • might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior (Kong 2004)
  • having a function in germ cells unrelated to any specific developmental stage (Gjerstorff 2007)
  • can elicit both cellular and humoral immune responses, indicating that they are appropriate targets for cancer immunotherapy (Gjerstorff 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular defense response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS