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FLASH GENE

Symbol

FCRL4

contributors: mct - updated : 20-09-2016

HGNC name	Fc receptor-like 4
HGNC id	18507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	component of a cluster of five IRTAs genes, contiguously located 1q21
STRUCTURE	24.33 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031282 12 - 3459 NP_112572 - 515 - 2002 11929751

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Lymphoid/Immune lymph node           tonsils

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	four extracellular Ig type domains
	three potential N glycosylation type
	a cytoplasmic domain with three putative consensus SH2 binding domain

HOMOLOGY

Homologene

FAMILY

immunoglobulin like receptor family

CATEGORY

immunity/defense , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing a role in regulating activation of normal B cells and possibly in the development of neoplasia
	playing a role in the immune function of B cells within epithelia
	may act as a molecular switch in B cells to dampen adaptive immune signaling and enhance innate signaling in response to chronic antigenic stimulation
	function to costimulate or inhibit BCR signaling through consensus ITAMs and ITIMs
	FCRL4 and FCRL5 are likely to be important for immune complex-dependent human B cell regulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

other,

bound efficiently to IgA

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	first positive marker for marginal zone lymphomas, enabling more accurate diagnosis of these neoplasms
	FCRL4 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs)
Therapy target
	System Type Disorder Pubmed immunology autoimmune   represent novel therapeutic target for receptor blockade therapies

ANIMAL & CELL MODELS