Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | DHRS2 | contributors: mct - updated : 10-11-2010 |
HGNC name | dehydrogenase/reductase (SDR family) member 2 |
HGNC id | 18349 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 9.28 kb 9 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter (TATA box) |
alternative promoter | |
Binding site | |
text structure | |
|
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
|
cells |
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cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | fetal |
Text | liver,pancreas |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
isoforms | Precursor | preprotein contains an N-terminal mitochondrial targeting signal that is cleaved following mitochondrial import, resulting in mitochondrial matrix accumulation of mature Hep27 |
HOMOLOGY |
Homologene |
FAMILY |
CATEGORY | enzyme , transport |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,matrix | |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus | |
text | |
| |
|
basic FUNCTION | |
| |
| |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
unique MYB-DHRS2-MDM2-TP53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
Other | regulated at the transcriptional level by the proto-oncogene MYB and is required for MYB-induced TP53 stabilization |
ASSOCIATED DISORDERS |
ANIMAL & CELL MODELS |