Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | EIF4A2 | contributors: mct - updated : 02-09-2020 |
HGNC name | eukaryotic translation initiation factor 4A, isoform 2 |
HGNC id | 3284 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 6.32 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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|
EXPRESSION |
Type | ubiquitous |
tissue |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
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HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | enzyme , RNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic,ribosome | |
text |
basic FUNCTION | |
| |
| |
| |
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CELLULAR PROCESS | protein, translation/synthesis |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
|
cell & other |
REGULATION |
Other | EIF4A2 is modified by SUMO, with sumoylation occurring on a single residue (K226), and inability to sumoylate EIF4A2 results in impaired stress granule formation, indicating a new role for sumoylation in the stress response |
ASSOCIATED DISORDERS |
corresponding disease(s) | NDIDHE |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene | to type 2 diabetes in French families |
Marker | |
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Therapy target
| |
ANIMAL & CELL MODELS |