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FLASH GENE

Symbol

KLF3

contributors: mct - updated : 28-10-2010

HGNC name	Kruppel-like factor 3 (basic)
HGNC id	16516

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	37.34 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	driven primarily by two promoters, a ubiquitously active GC-rich upstream promoter, 1a, and an erythroid downstream promoter, 1b. (transcripts from the two promoters encode identical proteins, but both the ubiquitous and the erythroid promoter are dependent on KLF1 in erythroid cells)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	six alternatively spliced transcripts encoding altogether four proteins (ACE/NCBI)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016531 6 - 5632 NP_057615 - 345 - 2003 12812068

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol   digestive Blood/Hematopoietic erythroid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a PVDLS sequence required for contact with GTBP1
	a highly conserved 81 AA DNA binding domain
	a stretch of basic residues
	three Krüppel related zinc fingers at the C terminus

HOMOLOGY

interspecies

homolog to murine Klf3

Homologene

FAMILY	CACCC binding zinc finger family
	krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcriptional corepressor with CTBP1 involved in hematopoiesis
	transcriptional regulator of muscle genes, which may play an important role in muscle differentiation
	CACCC box binding factor in erythroid cells, and bind C(A/C)CACCC with particularly high affinity

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	hematopoietic differentiation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding CACCC box containing proteins

RNA

small molecule

protein	CTBP1 acting with KLF3 as a repressor for a number of transcription factors
	associate with CTBP2 and FHL3, which mediate its repressive effects on gene transcription
	binds the CEBPA promoter and both are implicated in controlling adipogenesis
	represses the Klf8 (Krüppel-like Factor 8) gene
	interacting with SRF (physically associate and synergize in transactivating the CKM (Muscle creatine kinase) promoter independently of SRF binding to CArG motifs

cell & other

REGULATION

activated by

KLF1 (directly activates KLF3)

induced by

erythroid Krüppel like factor EKLF (KLF1)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to progressive myeloproliferative disorder

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

BKLF deficient mice exhibit a myeloproliferative disorder