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FLASH GENE
Symbol KIF15 contributors: mct - updated : 27-04-2020
HGNC name kinesin family member 15
HGNC id 17273
DNA
TYPE functioning gene
STRUCTURE 91.53 kb     35 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
35 - 4760 - 1388 - 2019 30797758
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland    
Hearing/Equilibriumearinnercochlea  
Nervousbrain     Homo sapiens
 nervecranial nerve   
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one myosin tail
  • a kinesin motor domain
  • mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to murine Kif15 (86.2pc)
    homolog to rattus Kif15 (85.2pc)
    Homologene
    FAMILY kinesin-like protein family
    CATEGORY motor/contractile , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • may be involved in control of cell proliferation
  • similar to KIF11, KIF15 can drive centrosome separation during bipolar spindle assembly
  • mitotic motor protein that continues to be expressed in developing neurons
  • mitotic microtubule-associated motor protein, impacting axonal growth, navigation, and branching
  • acts predominantly on kinetochore fibers to regulate their lengths
  • KIF15 bound to kinetochore fibers antagonizes centrosome separation while KIF15 bound to nonkinetochore MTs mediates centrosome separation
  • KIF11, KIF15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation
  • plays a crucial role in assembly and maintenance of the mitotic spindle
  • cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles
  • participates in important events during neuronal development, such as cell division of neuronal precursors, migration of young neurons and establishment of axons and dendritic arbors, by regulating microtubule organization
  • both KIF15 and KIFBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length
  • is a critical regulator that promotes pancreatic cancer proliferation
  • function in many different cellular processes, including proliferation, apoptosis, differentiation and development
  • KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division
  • could play a critical role in the regulation of cell proliferation of hepatocellular carcinoma (HCC)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • MKI67 (for the progression of mitosis)
  • KIFBP is a specific interaction partner of KIF15 in mitosis, and promotes the localization of KIF15 to the spindle equator close to the chromosomes
  • KIFBP reduces the activity of KIF18A and KIF15 during metaphase (directly inhibits KIF18A and KIF15 motor activity by preventing microtubule binding)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in glioma tumor tissues and positively correlated with pathological staging, recurrence risk and poor prognosis
    tumoral       gain of function
    in human pancreatic cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • served as a prognostic indicator for glioma
  • may serve as a novel diagnostic target for melanoma, especially uveal melanoma
  • higher KIF15 expression levels correlated with shorter patient survival times in pancreatic cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    may be a therapeutic target for glioma therapy
    cancerdigestiveliver
    KIF15 could be a novel therapeutic target for the treatment of hepatocellular carcinoma (HCC)
    cancereye 
    therapeutic target for melanoma, especially uveal melanoma
    ANIMAL & CELL MODELS