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FLASH GENE
Symbol PACSIN3 contributors: mct/npt - updated : 26-09-2017
HGNC name protein kinase C and casein kinase substrate in neurons 3
HGNC id 8572
DNA
TYPE functioning gene
STRUCTURE 8.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1894 - 424 - 2012 22573331
11 - 1913 - 424 - 2012 22573331
11 - 2046 - 424 - 2012 22573331
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineadrenal gland    
Reproductivefemale systemuteruscervix highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cdc 15 domain
  • one FES/CIP4 homology domain
  • one central coiled coil domain
  • a F-BAR domain
  • a SH3 domain at the C terminus, involved in interaction with TRPV4 (requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of the channel and the C-terminal Src homology 3 domain) (Cuajungco 2006), SH3 domain-mediated autoregulation of the membrane-deforming activity of F-BAR domains that is of crucial importance for its function (Rao 2010)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pacsin 3
    Homologene
    FAMILY
  • PACSIN family
  • Fer-CIP4 homology-BAR (F-BAR) family
  • CATEGORY adaptor , signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text functional interaction with TRPV4 could be important in cell types that show distribution of both proteins to the same subcellular regions such as renal tubule cells where the proteins are associated with the luminal plasma membrane (Cuajungco 2006)
    basic FUNCTION
  • playing a role in vesicle formation and transport
  • may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation
  • in addition to a crucial role in endocytic internalization, complexes with EHDs play an important role in endocytic receptor recycling
  • acting as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner
  • function in dynamic microtubuli nucleation
  • intracellular adapter protein involved in vesicle transport, membrane dynamics and actin reorganisation
  • participate in cellular membrane trafficking, in regulation of dynamin-mediated endocytotic processes and have been shown to generate membrane tubules (Wang 2009)
  • novel function for PACSIN1, PACSIN2, PACSIN3 in dynamic microtubuli nucleation
  • wedge loop of PACSIN3 is more rigid as PACSIN1, PACSIN2, which influences the lateral interactions between assembled dimers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with EHD1, EHD2
  • components of the centrosome involved in microtubule dynamics
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 zinc ion per subunit
  • protein
  • ADAM15
  • binding ADAM12( its proline-rich region required for binding)
  • specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization of the ion channel (Cuajungco 2006)
  • role for PACSIN3 in regulating glucose uptake in adipocytes via its preferential participation in SLC2A1 trafficking
  • exists in a persistent colocalized state with DNM1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS