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FLASH GENE
Symbol SPA17 contributors: - updated : 17-09-2005
HGNC name sperm autoantigenic protein 17
HGNC id 11210
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa
cell lineage
cell lines testis cancer cell lines
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one Iq domain
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Spa17
Homologene
FAMILY cancer-testis antigen family
CATEGORY regulatory , antigen
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • important role in cell migration and/or adhesion in somatic cells as well as in male germ cells
  • involved in the interaction of the spermatozoa with the zona pellucida of the oocyte surrounding extracellular glycoprotein matrix
  • cancer-testis antigen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS