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FLASH GENE
Symbol CPM contributors: mct - updated : 24-04-2020
HGNC name carboxypeptidase M
HGNC id 2311
DNA
TYPE functioning gene
STRUCTURE 121.05 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • an upstream promoter sequence containing several transcription factor binding sites
  • two unique functional promoters: one ('proximal') is immediately upstream of the coding region and contains GC-rich sequences and a typical TATA box whereas the other ('distal') consists almost entirely of repetitive elements
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 6683 50 443 - 2013 24108126
    9 - 6627 50 443 - 2013 24108126
    9 - 6651 50 443 - 2013 24108126
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarybladder   highly
     kidneytubulecollecting duct highly Homo sapiens
     kidneytubuleconvoluted tubuledistal tubule  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • hydrophobic domains at the N and C termini
  • a conserved catalytic domain including six glycosylation sites
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • carboxypeptidase M cleaving basic C terminal amino acids in monocyte to macrophage differentiation
  • membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins 1)
  • likely a cellular player in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
  • could likely promote foam cell formation by acting in the lipid regulation process of macrophages
  • inhibition of CPM, the key enzyme involved in the biosynthesis of BDKRB1 agonists, could exert the same beneficial effects to BDKRB1 antagonism in insulin resistance
  • is a glycosylphosphatidylinositol anchored enzyme that plays an important role in the kallikrein-kinin system (KKS)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • activating peptide hormones at local tissue sites, before or after binding to their ligands
  • close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
  • spatial proximity between ACE and the endogenous CPM BDKRB1 signals, which play important r enables an ACE-evoked release of CPM
  • BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several tumor tissues
    tumoral     --over  
    in renal clear cell carcinomas
    tumoral   amplification    
    in well-differentiated liposarcomas/atypical lipomatous tumor
    Susceptibility to silicosis
    Variant & Polymorphism other
  • rs12812500 variant of the CPM gene may increase silicosis susceptibility
  • Candidate gene
    Marker
  • CPM is a novel marker in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
  • identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    therapeutic target in insulin resistance
    ANIMAL & CELL MODELS