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FLASH GENE

Symbol

SLC4A8

contributors: mct - updated : 08-04-2014

HGNC name	solute carrier family 4, sodium bicarbonate cotransporter, member 8
HGNC id	11034

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	124.45 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	Viral sequence   long terminal repeat
text structure	specific HERV-K LTR within intron 5

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004858 22 - 4010 NP_004849 - 1044 - 2008 1857771 NM_001039960 25 - 11794 NP_001035049 - 1093 - 2008 1857771 NM_001258401 25 - 11740 NP_001245330 - 1040 - 2008 1857771 NM_001267615 15 - 2278 NP_001254544 - 638 - 2008 1857771 NM_001258402 15 - 2332 NP_001245331 - 691 - 2008 1857771 NM_001258403 - - 3131 NP_001245332 - 747 - 2008 1857771

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Nervous brain         Homo sapiens   brain forebrain cerebral cortex     Mus musculus   brain         Rattus norvegicus Adult   brain forebrain cerebral cortex     Mus musculus   brain hindbrain cerebellum     Mus musculus   brain limbic system hippocampus     Mus musculus Reproductive male system testis       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Muscular striatum skeletal     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell Mus musculus Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminal PDZ-interacting motifs

HOMOLOGY

interspecies

homolog to murine Ncbe

intraspecies

homolog to SLC4A5

Homologene

FAMILY	anion exchanger (TC 2.A.31) family
	SLC4 family of bicarbonate transporters

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive GABAergic cells

basic FUNCTION	playing an essential role in maintaining sensory cells integrity in both visual and auditory systems
	having inorganic anion exchanger activity
	is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons
	potential role in mediating substantial Na+ reabsorption in the cortical collecting duct (CCD)
	modulates potentially glutamate release in a pH-dependent manner
	modulate excitatory neurotransmission in hippocampus
	can regulate glutamatergic transmission throughout the brain, and is a possible regulator of GABAergic neurotransmission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CA2 interacts at high affinity with the C-terminal (Ct) domains of SLC4A8, but can bind to GST-SLC4-Ct fusion proteins only when the CA2 is immobilized and the fusion protein is soluble, and not vice versa

cell & other

REGULATION

Other

its activity is inhibited by PRKACA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS