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FLASH GENE
Symbol CPEB1 contributors: mct - updated : 23-06-2011
HGNC name cytoplasmic polyadenylation element binding protein 1
HGNC id 21744
DNA
TYPE functioning gene
STRUCTURE 104.78 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3202 - 561 - 2001 11223249
isoform 1
11 - 3110 - 491 - 2001 11223249
isoform 2
10 - 3196 - 486 - 2001 11223249
isoform 3
11 - 3095 - 486 - 2001 11223249
isoform 3
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA recognition motif
  • HOMOLOGY
    Homologene
    FAMILY
  • cytoplasmic polyadenylation element (CPE) binding protein family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
    basic FUNCTION
  • involved in some forms of synaptic plasticity
  • regulate translation of cyclin B1 during embryonic cell divisions
  • number and relative positions of CPE-binding element in 3'UTR determine whether an mRNA is translationally repressed by CPEB as well as the extent and time of polyA-dependent translational activation
  • stimulates polyadenylation and translation in germ cells and neurons
  • spindle-localized translational activation of CPEB1-regulated mRNAs, encoding proteins with a known function in spindle assembly and chromosome segregation, is essential for successful chromosome segregation during the first meiotic division and for the G1-G2 transition
  • controls senescence and bioenergetics in cells at least in part by modulating Tp53 mRNA polyadenylation-induced translation
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • controlling translation with CPEB4 and thus regulating mitotic cell-cycle progression
  • inducing cytoplasmic polyadenylation of dormant mRNAs with short polyA tails resulting in their translation
  • regulating translation of cyclin B1 during embryonic cell divisions
  • mediating polyadenylation in prophase I and metaphase I of meiosis
  • has dual functions as a translational repressor and activator
  • CPEB1 and CPEB4 are differentially regulated by phase-specific kinases, generating the need of two sequential CPEB activities to sustain cytoplasmic polyadenylation during all the meiotic phases
  • CPEB1-mediated TJP1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE) found in the 3'UTR of some mRNAs
    small molecule
    protein
  • interacting with CPEB4 (establishes a new meiotic circuit by activating the synthesis of CPEB4, which, in turn, compensates for the inactivation and degradation of CPEB1 by mediating cytoplasmic polyadenylation in the second meiotic division)
  • interacting with CDC73
  • is bound and represses cyclin B1 mRNA translation until a signal to proliferate phosphorylates CPEB1, resulting in an increase in cyclin B1 protein and progression into mitosis
  • CPEB1 and PAPD4 are antagonizing factors regulating TP53 mRNA stability
  • PIN1 is an important factor mediating CPEB1 destruction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    unregulated translation of Myc in Cpeb -/- mouse embryonic fibroblasts may cause them to bypass senescence