basic FUNCTION
| involved in some forms of synaptic plasticity |
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regulate translation of cyclin B1 during embryonic cell divisions |
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number and relative positions of CPE-binding element in 3'UTR determine whether an mRNA is translationally repressed by CPEB as well as the extent and time of polyA-dependent translational activation |
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stimulates polyadenylation and translation in germ cells and neurons |
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spindle-localized translational activation of CPEB1-regulated mRNAs, encoding proteins with a known function in spindle assembly and chromosome segregation, is essential for successful chromosome segregation during the first meiotic division and for the G1-G2 transition |
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controls senescence and bioenergetics in cells at least in part by modulating Tp53 mRNA polyadenylation-induced translation |
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regulate translation by binding to regulatory motifs of defined mRNA targets |
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controlling translation with CPEB4 and thus regulating mitotic cell-cycle progression |
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inducing cytoplasmic polyadenylation of dormant mRNAs with short polyA tails resulting in their translation |
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regulating translation of cyclin B1 during embryonic cell divisions |
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mediating polyadenylation in prophase I and metaphase I of meiosis |
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has dual functions as a translational repressor and activator |
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CPEB1 and CPEB4 are differentially regulated by phase-specific kinases, generating the need of two sequential CPEB activities to sustain cytoplasmic polyadenylation during all the meiotic phases |
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CPEB1-mediated TJP1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity |