basic FUNCTION
| having functions in the specification of a neural precursor state |
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essential role in spinal cord development |
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acts as a master regulator of intermediate tubule fate |
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first gene known to be necessary and sufficient to specify nephron segment fate |
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with IRX1, are required for proper formation of the intermediate renal tubule |
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critical role in the precise regulation of intercellular gap junction coupling and impulse propagation in the heart |
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required for normal ventricular activation |
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unique transcriptional regulator of rapid electrical conduction that is necessary to drive ventricular activation |
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important for certain postnatal cardiac functions, the rapid ventricular conduction |
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IRX3 functions as a transcriptional repressor in mediating thalamic competence and antagonizing this repressor function impaired thalamic specification |
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IRX3 and IRX5 can work together to regulate mineralization of specific cranial bones |
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