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FLASH GENE
Symbol ACVR1C contributors: mct/npt - updated : 15/10/2008
HGNC name activin A receptor, type IC
HGNC id 18123
DNA
TYPE functioning gene
STRUCTURE 102.12 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 8892 54.7 493 - Roberts (2003)
9 splicing 8777 49.6 443 - Roberts 2003
  • containing a distinct 5' UTR and lacking an in-frame portion of the 5' coding region compared to variant 1
  • also known as tALK7
  • lacking part of the activin receptor-binding domain
  • 8 splicing 8652 46.2 413 - Roberts (2003)
  • lacking an alternate in-frame exon in the coding region compared to variant 1
  • also known as sALK7a
  • lacking the transmembrane and GS domains
  • 7 splicing 8421 37.3 336 - Roberts (2003)
  • lacking two alternate in-frame exons in the coding region compared to variant 1
  • also known as sALK7b
  • lacking the transmembrane domain, GS domain, and part of the kinase domain
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  specific
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines insulinoma cell line MIN6
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 20 aa signal peptide
  • a cysteine-rich extracellular region
  • a GS domain
  • a cytoplasmic serine/threonine kinase domain
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Acvr1c (92.7 pc)
    homolog to murine Acvr1c (95.9 pc)
    intraspecies paralog to nodal
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • transforming growth factor beta subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • acting as a serine/threonine protein kinase
  • being a receptor for activin AB, activin B and NODAL
  • playing a role in cell differentiation, growth arrest and apoptosis
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text regulation of apoptosis
    PATHWAY
    metabolism
    signaling signal transduction
    signaling through MADH2 after activation by NODAL
    a component
  • forming a stable complex with type II receptor after ligand binding
  • complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • Mg2+
  • Mn2+
  • ATP
  • protein
  • binding the type 2 receptor protein ACVR2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS