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FLASH GENE
Symbol RNF19A contributors: npt - updated : 12-05-2005
HGNC name ring finger protein 19A
HGNC id 13432
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two variants encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4366 90 838 - -
- - 4357 90 838 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousspinal cord    
Reproductivefemale systemuterus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney and testis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an IBR (in between RING fingers) motif at the N terminus
  • two RING-finger motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • RING finger type ubiquitin ligase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text localized in Lewy bodies
    basic FUNCTION
  • mediating ubiquitination of cellular proteins
  • may be involved in the pathogenic process of Parkinson disease and Lewy bodies formation by ubiquitylation of synphilin-1 (SNCAIP)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes
  • binding and ubiquitylating synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of Lewy-Bodies
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS