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FLASH GENE
Symbol PAPOLG contributors: npt - updated : 19-07-2006
HGNC name poly(A) polymerase gamma
HGNC id 14982
DNA
TYPE functioning gene
STRUCTURE 42.72 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text displaying distinct mRNA splice varaints (Topalian)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4252 82.8 736 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved cyclin recognition motif
  • a multiple potential cyclin-dependent kinase (Cdk) phosphorylation sites
  • a U1A protein-interacting region in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • poly (A) polymerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polynucleotide adenylyltransferase
  • catalyzing template-independent (adenylation) extension of the 3' end of a DNA/RNA strand
  • exhibiting both non specific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA processing,mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • component of pre RNA polyadenylation complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • U1A protein
  • cell & other
    REGULATION
    inhibited by U1A protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS