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FLASH GENE
Symbol KLC1 contributors: shn/npt - updated : 03-10-2017
HGNC name kinesin light chain 1
HGNC id 6387
DNA
TYPE functioning gene
STRUCTURE 72.36 kb     16 Exon(s)
text structure The first exon contains the 5'-untranslated sequence capable of forming a stable double-hairpin loop, which functions as a translational enhancer
MAPPING cloned Y linked N status confirmed
Map cen - D14S293 - D14S118 - KLC1 - D14S1010 - D14S260 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2530 - 618 Brain, Spinal Cord, Sciatic Nerve Rahman (1998), Gyoeva (2000)
15 - 2624 64.8 560 Brain, Spinal Cord, Sciatic Nerve Rahman (1998), Gyoeva (2000)
15 - 2399 - 573 Brain, Spinal Cord, Sciatic Nerve Rahman (1998), Gyoeva (2000)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Lymphoid/Immunespleen   lowly
Nervousbrain   highly
Reproductivemale systemtestis  lowly
Respiratorylung   specific
Urinarykidney   lowly
Visualeye   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus with heptad repeats typical of the rod domain of cytoskeletal proteins
  • six tetratricopeptide repeat (TPR)
  • a central and C terminal consisting of 27 repeats of approximately 21 amino-acids, mediating binding to cargoes
  • mono polymer tetramer
    HOMOLOGY
    interspecies ortholog to Klc1, Mus musculus
    ortholog to Klc1, Rattus norvegicus
    ortholog to klc1, Danio rerio
    ortholog to KLC1, Pan troglodytes
    Homologene
    FAMILY
  • kinesin light chain family
  • CATEGORY motor/contractile , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text specific for the Golgi complex (Gyoeva 2000)
    basic FUNCTION
  • may be playing a role in organelle transport
  • light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
  • involved in dendritic and axonal transport in the brain, is affected during chronic morphine treatment and may be involved in the development of opioid addiction (Bilecki 2009)
  • complex of KLC1, KIF5C and CRMP2 is involved in transporting tubulin heterodimers and oligomers to the tip of the growing axon
  • KLC1 may potentially compete with MAP1LC3A, a key component for autophagosome formation, to interact with FUNDC1
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text transport of organelles
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with two kinesins, heavy chain and two light chains (KIF5A, KIF5B, KLC2, KLC1) (Morton 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinesin family member 5C (KIF5C) and collapsin response mediator protein 2 (CRMP2)
  • mitogen-activated protein kinase 8 interacting protein 3, MAPK8IP3(
  • amyloid precursor protein, APP (
  • SNAP25 and SNAP23 (
  • JNK-interacting protein 1, JIP1 (
  • sperm associated antigen 9, SPAG9 (
  • caytaxin binds to KLC1 and functions as an adaptor that mediates intracellular transport of specific cargos, one of which is the mitochondrion
  • cytoplasmic amino N-terminal domain of FUNDC1 is essential for interaction with KLC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leading to axonal transport defects and gain of function of MAPT can initiate neurodegeneration and/or exacerbate human tau-dependent disease pathways in AD and other neurodegenerative tauopathies
    Susceptibility
  • to Alzheimer disease
  • to multiple scerosis (MS)
  • Variant & Polymorphism other
  • polymorphisms increasing the risk of Alzheimer disease
  • 56836CC variant proved to exert a significant protective effect on the occurrence of MS (Szolnoki 2007)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • KLC1 gene-targeted mice results in significantly smaller mutant mice that also exhibited pronounced motor disabilities (
  • in living mice carrying a deletion of the kinesin light chain 1 (KLC1&
  • 8722;/&
    8722;) motor subunit revealed delayed axonal transport rates, and t early and selective transport defects can activate c-Jun N-terminal stress kinase (JNK) pathways that initiate abnormal hyperphosphorylation of tau in the absence of Abeta toxicity (
  • mislocalization of opsin is a major cause of photoreceptor cell death from kinesin-2 dysfunction (