basic FUNCTION
| transcriptional coactivator, preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic |
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reticulum (ER) |
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cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line |
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is a new factor involved in the positive regulation of human erythroid-cell differentiation |
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may act as a specific coactivator for JUN, binding to DNA |
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and stabilizing the interaction of JUN homodimers with target gene promoters |
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participates in the proper maturation of newly synthesized proteins |
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its degradation triggers ER stress responses and initiates apoptotic processes in hypoxic cells, and GSK3B may participate upstream in this mechanism |
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plays potentially a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration |
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plays a role in regulating gene transcription during mesenchymal cell differentiation by differentially recruiting corepressors at target promoters |
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controls myoblast migration and sarcomere architecture in a calpain-dependent manner |