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FLASH GENE
Symbol GPS1 contributors: mct/npt - updated : 05-05-2009
HGNC name G protein pathway suppressor 1
HGNC id 4549
DNA
TYPE functioning gene
STRUCTURE 5.58 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1870 56.7 491 - Spain, Ewing (2007)
13 - 2364 - 527 - Spain, Ewing (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PCI (Proteasome,COP9,initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
  • HOMOLOGY
    interspecies homolog to murine Gps1
    Homologene
    FAMILY
  • CSN1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potential cellular regulator modulating multiple signaling pathways
  • phosphorylating IKBA, JUN, NFKB1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    suppressor of G-protein and mitogen activated protein-kinase mediated pathways
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ASB4 to inhibits JNK activity (Li 2007)
  • GPS1 targets SENP8 for protein degradation, and GPS1-SENP8 interaction that affects SENP8 protein levels presumably balances cellular deneddylase activity
  • cell & other
    REGULATION
    activated by protein-kinase mediated pathways
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS